ISAC PHADIA PDF

It is the result of a combination of innovative biochip technology and cutting edge research in molecular allergology. It is the only in vitro diagnostic test for simultaneous measurement of specific IgE antibodies to a broad spectrum of allergen components. How do they work? The biochip technology takes the form of a miniaturised immunoassay platform where allergen components are immobilised in a microarray. The allergen components are spotted in triplets and covalently immobilised on a polymer coated slide.

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The first steps towards the present Phadia AB were taken in the mid s. At the same time an important medical discovery was made which would be of decisive importance to Phadia.

Johansson and Bennich worked together with Wide to develop a method to measure the levels of the substance in blood samples.

Eventually a clear connection was demonstrated between IgE antibodies and allergic symptoms. Johansson, Bennich and Wide then suggested that Pharmacia should use the findings to develop a commercial allergy test. This led to the ground-breaking product Phadebas RAST , which established the leading position that Phadia still maintains in the area of allergy testing.

Immunoglobulin E testing[ edit ] Since the discovery of IgE in , Phadia has pioneered the development of in vitro test systems for allergy immunoglobulin E. These IgE tests have been followed by tests for IgG and IgA antibodies , as well as other analytes with applications in asthma , celiac disease and autoimmunity. In addition, the ImmunoCAP testing system has revolutionized the level of automation and speed which these tests are processed.

Based on the high binding capacity and solid phase technology, ImmunoCAP tests are both highly sensitive and highly specific.

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